National Core Facility for Biopharmaceuticals

MOC

Resource Center for Model OrganismsChau-Ti Ting, Professor

Resource Center for Model Organisms integrates research communities focused on nematodes, fruit flies, and yeast. This integration aims to explore genes associated with human diseases using multiple model species. The center collaborates actively with clinical physicians, offering consultation services to establish disease models in model organisms. These models are engineered to express disease-related characteristics, facilitating the study of disease mechanisms.
Services provided by the strain center include:
1. Application and short-term storage of imported strains for domestic labs.
2. Long-term maintenance of widely used yeast, nematode, and fruit fly strains.

Gene transduction and editing platform:
1. Approximately 50 fruit fly and nematode gene transduction services per month.
2. Development of site-specific gene transduction and CRISPR-Cas9 gene editing techniques to create disease models.
3. Point mutation editing for fruit flies and nematodes.

Molecular resource library services:
1. Regular ordering of antibodies from the Hybridoma Bank.
2. Collection, preservation, and provision of common vectors, plasmids, and gene libraries for Taiwanese researchers.
3. Plans to establish a protein antibody resource, producing 5 common antibodies yearly for yeast-based researchers to apply for.

Disease model consultation and establishment platform:
1. Offering consultation and establishment services for using model organisms as disease models.
2. Services include comparing homologous genes, mutant strains, transgenic services, gene knockout and replacement, survival analysis, and integration with vertebrate models.

Drug screening analysis platform:
1. Providing a drug screening platform, including assessment of "anti-aging effects of health foods" and "high-throughput drug screening."
2. Developing alternative vertebrate testing platforms in line with the government's 3R policy.

Model organism community resource network and education:
1. Providing electronic resources and online courses for model organism research.
2. Annual collective educational and operational training courses during breaks.

http://flycoretw.lifescience.ntu.edu.tw/

Acknowledgment template：

We express our gratitude to the Resource Center for Model Organisms of the National Core Facility for Biopharmaceuticals for generously providing biological resources, reagents, and related services.