National Core Facility for Biopharmaceuticals

SB2

The establishment of a clinico-pathological network and databaseon hepatocellular carcinoma in Taiwan and Taiwan lung cancer tissue/specimen and information resource centerShiu-Feng Huang

Hepatocellular carcinoma (HCC) and Lung cancer are the 2 leading cancer deaths in Taiwan. Thus, these 2 cancers are the most important cancers in Taiwan, and both have been chosen as the main target diseases by National Research Program. NRPGM has supported the establishment of a liver cancer research network since 2005 (Taiwan Liver Cancer Network, TLCN), which coordinated 5 major medical centers in northern, central, and southern parts of Taiwan (NTUH, CGMH-Linko, Taichung VGH, CGMH-Kaohsiung, Kaohsiung VGH) to recruit liver cancer patients with regional representativeness. All participating centers followed a common protocol to collect liver cancer specimens as well as the patients’ clinical, pathological and epidemiological information. All samples and data are saved in the National Health Research Institutes Biobank with good management. National Health Research Institutes Biobank has been approved by the Ministry of Health and Welfare. During these years, lung cancer has overcome HCC, and becomes the leading cancer death in Taiwan. Thus, we have followed the successful model of TLCN to start the establishment of a lung cancer tissue resource center in 2015, which also coordinate 5 major medical centers (NTUH, CGMH-Linko, Chung-Shan Medical University Hospital, CGMH-Kaohsiung, Kaohsiung VGH). Currently, we already recruited 17,109 participants, received 222 applications, which included 9 applications from the domestic industries. and sent out 96,517 biospecimens to the applicants by the end of April, 2023. Our applicants have published 123 papers, and 23 of them were in the journals with impact factor >10. We are the best Biobank in Taiwan. The final goal of this project is to improve the treatment and survival of liver cancer and lung cancer patients in Taiwan through successful researches in the cancer mechanism, prevention, screening, early detection and therapies.

http://biobank.nhri.org.tw

Acknowledgment template：

“We would like to thank The National Health Research Institute Biobank and its cooperative institutions for providing the biological specimen and related clinical data (all are de-identified) for our research. National Health Research Institute Biobank is supported by grants from Ministry of Health and Welfare, National Science and Technology Council and National Health Research Institutes, Taiwan.”